Active substance: Spironolactone

Dosage: 25 mg, 100 mg

Price: €27.92 – €285.04

Aldactone is a diuretic that reduces potassium and magnesium. The increased diuresis causes a hypotensive effect; the diuretic effect during therapy with the drug is obtained on the 2nd-5th day of administration. You can buy Aldactone in our online pharmacy at the lowest price in United Kingdom and with fast delivery to any corner of the country. We ship medicines without a prescription, so all you have to do is fill in a simple order form and we will notify you that the medicine is already in distribution. Take care of your health!

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The Over-the-Counter Medication in an Online Pharmacy

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What is Aldactone?

Aldactone is a diuretic tablet, available in 25 mg and 100 mg doses. The main active ingredient, spironolactone, promotes the excretion of urine from the body and reduces the excretion of calcium and urea.

The diuretic effect is obtained from the second to the fifth day of taking the drug.

Indications for use of Aldactone

Aldactone tablets are indicated for:

  • oedema in nephrotic syndrome;
  • oedemas due to chronic heart failure
  • cirrhosis of the liver
  • arterial hypertension
  • primary hyperaldosteronism
  • adrenal adenoma;
  • hypokalaemia;
  • prevention of hypokalaemia;
  • premenstrual syndrome
  • polycystic ovary syndrome;
  • oedema in pregnant women in the second and third trimester.

Dosage and administration

Dosage and duration of treatment are determined individually and depend on the symptomatology and hormonal status.

The tablets are taken orally with water. Dosage for oedema: the daily dose is 100-200 mg, divided into two or three doses per day. Sometimes 300 mg is prescribed, depending on the severity of the disease. Aldactone treatment is mainly prescribed in combination with thiazide or loop diuretics. The duration of treatment is 2-3 weeks.

In cases of potassium depletion or hyperaldosteronism, the 300 mg dose is divided into 2-3 daily doses.


Aldactone should not be prescribed in cases of:

  • Anuria;
  • hepatic or renal insufficiency
  • hyperkalaemia;
  • hypercalcaemia
  • hyponatraemia;
  • diabetes mellitus and diabetic nephropathy;
  • menstrual disorders;
  • metabolic acidosis;
  • enlargement of mammary glands;
  • in the first trimester of pregnancy;
  • sensitivity to any component of the medicinal product.

Side effects

The most common side effects that may accompany Aldactone treatment are:

  • nausea or vomiting
  • abdominal pain
  • gastrointestinal bleeding
  • gastritis
  • intestinal cramps
  • constipation
  • diarrhoea;
  • drowsiness;
  • dizziness or headache;
  • ataxia;
  • thrombocytopenia;
  • megaloblastosis;
  • agranulocytosis;
  • hyperuricemia;
  • hypercreatinemia;
  • gynaecomastia;
  • hormonal changes in the body (amenorrhoea, dysmenorrhoea, cellulitis, erectile dysfunction, breast pain);
  • allergic reactions (itching, urticaria, fever).

Special indications

Aldactone is contraindicated in the first trimester of pregnancy, while in the second and third trimester it is prescribed as indicated. Breast-feeding should be discontinued for the duration of treatment, as spironolactone enters breast milk in small doses.

Spironolactone should not be taken concomitantly with ACE inhibitors, other diuretics, salicylates, oral anticoagulants, digitotoxin, eprosartan, losartan, candesartan, lithium carbonate, noradrenaline, triptorelin, gonadorelin, buserelin. If you are taking any of the above medicines, you should inform your doctor.

An overdose of Aldactone has the following symptoms: nausea, vomiting, decreased blood pressure, skin rash, diarrhoea, weakness, arrhythmia, paraesthesia, myasthenia gravis, hypercalcaemia, hyponatraemia, dehydration, increased urea concentration. What to do in case of overdose?

Gastric lavage, then symptomatic treatment and restoration of water and electrolyte balance.

How many times a day should Aldactone be taken?

Depending on the dose, Aldactone is taken once a day or divided into two or three doses (200-300 mg).

When Does Spironolactone Start To Work?

The maximum therapeutic effect occurs 7 hours after taking the drug and lasts for at least 24 hours. The diuretic effect occurs 2 to 5 days after the start of treatment.

How many days should Aldactone be taken?

The duration of treatment with Aldactone is 14 to 21 days.

What Not to Eat

Alcohol should not be consumed during treatment with Aldactone, and it should also be noted that the medicine contains lactose.

Before or After Meals

It is recommended to take the medicine in the morning on an empty stomach or, if taking several doses a day, to take the tablets one or two hours after a meal.