Active substance: Amitriptyline

Dosage: 10 mg, 25 mg, 50 mg, 75 mg

Price: €36.77 – €329.53

Psycho-emotional disorders not only disrupt a person’s daily routine, but are also very harmful to health, as they lead to the risk of illness. Tricyclic antidepressants, including Endep, are prescribed to treat these disorders. The remedy is used to treat various depressions, bedwetting and obsessive-compulsive disorder. Buy Endep at the lowest price in United Kingdom is possible at our online pharmacy, where customers can find a wide range of quality-assured products. We will send you the ordered non-prescription medicine as soon as possible, all you have to do is fill in a simple online order form.

What is Endep

Endep is used to treat various types of depression and mental health problems. It comes in 10 mg, 25 mg, 50 mg and 75 mg tablets. The main active ingredient is amitriptyline.

Indications for use of Endep

It is used to treat patients suffering from depression, anxiety, phobias, psychogenic anorexia, bulimic neurosis, migraine prophylaxis and childhood enuresis.

Directions for use and dosage

The tablets are taken orally with or after meals – 50-75 mg per day, divided into 2-3 doses, gradually increasing the dose by 25-50 mg to achieve the desired antidepressant effect. The therapeutic dose is 150-200 mg per day, divided into several doses, but most should be taken in the evening. In cases of severe depression, the dose can be increased to 300 mg per day. Once the antidepressant effect has been achieved, the dose should be gradually reduced.

In children over 6 years of age for nocturnal enuresis: before bedtime, 12.5-25 mg, maximum dose of 2.5 mg per kilogram of body weight.

Prevention of migraine or chronic pain of neurogenic origin: 12.5-100 mg per day.


Do not administer to patients allergic to any of the components of the drug, in case of toxic CNS depression, decompensated heart disease, myocardial infarction, hypertension, severe liver and kidney disease, glaucoma, peptic ulcer, bladder atony, prostatic hyperplasia, concomitant use with MAO inhibitors, during pregnancy and lactation, children under 6 years of age.

Side effects

The following adverse reactions may occur during drug therapy: drowsiness, arrhythmia, tachycardia, stomatitis, anorexia, nausea, vomiting, intestinal obstruction, hair loss, rash and pruritus, enlarged lymph nodes, gynecomastia, fever, decreased libido, decreased potency, urinary retention.