Metformin

Type 2 diabetes mellitus is a dangerous disease that carries a risk of stroke, myocardial infarction, neurological disorders, gangrene, visual impairment and kidney disease. If a patient is diagnosed with the disease, regular nutritional monitoring and medication to help normalise blood glucose levels are essential. One of the most commonly used drugs in type 2 diabetes is Metformin. You can buy Metformin at the lowest price in United Kingdom, with delivery anywhere in the country, in our online pharmacy. Fast delivery, good discounts and the possibility of buying without a prescription are some of the main reasons why more than a million customers choose our service.

Where to buy Metformin in United Kingdom

Ordering medication online at our online pharmacy is easy, convenient and will save you a lot of time. On our site you can always check the availability of the items you need and buy them at an attractive price.

Metformin Without Prescription Online Pharmacy

In our online pharmacy you can buy Metformin without prescription. Place an order on the site and the medicine will be shipped to you as soon as possible.

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What is Metformin

Metformin is an oral hypoglycaemic drug used in the treatment of diabetes. It comes in tablet form, with doses of 500 mg and 850 mg. Metformin reduces elevated blood glucose levels and its effect is independent of the secretory activity of the pancreas. The drug is prescribed for the treatment of diabetes in overweight people. Can metformin also be used without diabetes? Yes, it is effective for weight loss and also for weight loss in postmenopausal women. At the beginning of treatment, weight loss is more active because the drug accelerates metabolism.

Indications

Metformin is indicated for the treatment of type 2 diabetes, particularly in patients with lipid metabolism disorders and obesity, when blood sugar levels cannot be reduced by diet and exercise. The product is also used in combination with insulin and sulphonylurea derivatives.

Metformin Dosage and Administration

Tablets are taken orally, during or after meals. An initial dose of 500-1000 mg daily, one tablet should be taken 2 or 3 times. The dose is gradually increased until a positive effect is achieved. The maximum daily dose is 2550 mg. The therapeutic effect may not be felt immediately, but after two weeks of treatment, so the dose should not be increased too much.

Contraindications

Metformin is not prescribed for patients who have:

• Hypersensitivity to the components of the medicinal product;
• diabetic coma
• metabolic acidosis;
• lactic acidosis;
• hypoxic state;
• acute and chronic renal failure
• hepatic failure
• circulatory failure with tissue hypoxia;
• myocardial infarction;
• respiratory failure;
• severe burns;
• surgery;
• use of iodine-containing drugs;
• alcoholism;
• infectious diseases;
• pregnancy and lactation.

Side effects

The therapy may be accompanied by adverse reactions: loss of appetite, metallic taste in the mouth, abdominal pain, nausea, vomiting, diarrhoea, acidosis. To reduce these symptoms, it is necessary to take the drug with meals and to start with the lowest daily doses. Occasionally megaloblastic anaemia may occur with prolonged treatment. Very rarely the use of metformin is accompanied by lactic acidosis if the patient has renal, hepatic, respiratory and circulatory failure.

Overdose

Overdose may cause lactic acidosis, which should be treated with infusion therapy and, in severe cases, haemodialysis.

Special Indications

During treatment, the patient’s blood and urine glucose levels should be monitored. Metformin should be discontinued for a short period of time if surgery or iodine-containing drugs are required.

It should be noted that alcohol abuse, malnutrition, hypoglycaemic states, working with mechanical equipment and driving may occur in patients treated with Metformin and insulin combination therapy.

Pharmacological Interactions

The daily dose of metformin should be reduced if used concomitantly with probenecid, propranalol, rifampicin, sulphonamides, salicylates.

Cholesteramine, guar, oral contraceptives, diuretics, corticosteroids, isoniazid, phenytoin, nicotinic acid, chlorpromazine, thyroid hormones, sympathomimetics reduce the efficacy of the drug.

How many times a day should Metformin be taken?

The daily dose is usually divided into 2-3 doses.

When does the drug start to work?

The drug starts to work 2-2.5 hours after taking the tablets. The therapeutic effect can be reached 14 days after the start of treatment.

How many days do I have to take Metformin?

The medicine is taken regularly, according to the individually chosen dosage.

What not to eat

Pomegranate and grapefruit juice, alcohol, fast carbohydrates and smoked foods are undesirable.

Before or After Meals

It is recommended to take the tablets with or after meals to avoid lactic acidosis.