Active substance: Hydroxychloroquine

Dosage: 200 mg, 400 mg

Price: €34.52 – €1201.40

To treat malaria, rheumatoid arthritis or systemic lupus erythematosus, you need a medicine with a long-standing reputation for proven efficacy. Practitioners know what to recommend. Plaquenil, an immunosuppressant with antimalarial and amoebicidal properties, is exactly what you need!

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What is Plaquenil

Plaquenil tablets contain the active substance hydroxychloroquine. It is an immunosuppressant with antimalarial and amoebicidal properties.
It is indicated not only for the treatment but also for the prevention of malaria.

Plaquenil In COVID-19

Plaquenil (hydroxychloroquine) was not the recommended treatment for this viral disease (COVID-19), based on studies conducted during the COVID-19 pandemic.


Rheumatoid arthritis.
Juvenile rheumatoid arthritis.
Malaria caused by various susceptible strains, except chloroquine-resistant strains of Plasmodium falciparum.
Systemic lupus erythematosus.

Plaquenil Dose: 400 Mg 200 Mg

Adults: for the treatment of rheumatoid arthritis, a minimum dose of 6.5 mg per 1 kg body weight per day* is given.
The daily dose may correspond to 1 tablet of Plaquenil 400 mg or 1 tablet of Plaquenil 200 mg.

*The dose is calculated on the basis of ideal body weight, not actual body weight.

In children: for the treatment of rheumatoid arthritis, the minimum effective dose of 6.5 mg per 1 kg body weight is administered. The dose is calculated on ideal body weight, not actual body weight.

Plaquenil is not indicated in children weighing less than 31 kg.

Adults: for the prevention of acute malaria, Plaquenil 400 mg once a week on the same day of the week.

Children: for prevention of malaria, Plaquenil 6.5 mg per 1 kg bodyweight once a week on the same day of the week. Children with a body weight of less than 31 kg are not given Plaquenil.

Adults: For the treatment of acute malaria, 800 mg Plaquenil is administered, followed 6-8 hours later by 400 mg and the next 2 days by 400 mg. The total dose should not exceed 2 grams of the drug.

In children: for treatment of acute malaria, 32 mg per 1 kg (ideal weight is taken into account, not actual weight), but no more than 2 grams over 3 days, according to the following schedule:

  • The first dose is 12.9 mg per 1 kg, but not more than a single dose of 800 mg;
  • 6 hours after the first dose, the second dose is 6,5 mg per 1 kg, but not more than 400 mg;
  • 18 hours after the second dose, the third dose is 6,5 mg per 1 kg, but no more than 400 mg;
  • 24 hours after the third dose, the fourth dose is 6.5 mg per 1 kg, but not more than 400 mg.

Adults: for the treatment of systemic lupus erythematosus, an average starting dose of 400 mg Plaquenil 1-2 times daily for several weeks or months, depending on the patient’s response and condition. The maximum daily dose is 800 mg.

For long-term maintenance treatment, a lower dose of 200-400 mg daily of Plaquenil is sufficient.


Plaquenil tablets are taken orally with a glass of milk or a meal, accompanied by a few liquids.

The drug has cumulative properties, which means that its effect becomes apparent as it accumulates in the body. The maximum effect occurs after a few months, but side effects may occur soon after taking Plaquin.

If there is no improvement in the patient’s condition after 6 months of taking Plaquenil, the drug should be stopped and an alternative treatment sought.

Contraindications to Plaquenil

Pregnancy; children under 6 years of age; body weight less than 31 kg; retinopathy; lactose intolerance; lactase deficiency; galactosemia or glucose/galactose malabsorption syndrome.

Allergic reaction to 4-aminoquinoline derivatives.

Side effects

Skin manifestations: itching, rash, urticaria, redness, etc.
Effects on the digestive system: diarrhoea, nausea, flatulence, vomiting, etc.

Central and peripheral nervous system: dizziness, tinnitus, hearing loss, headaches, etc.

Side effects affecting the cardiovascular system are also possible.

Rarely: cardiomyopathy; retinopathy.

Any change in the patient’s usual condition is sufficient reason to discontinue treatment and seek detailed medical advice.

Frequently Asked Questions About Plaquenil

How often should Plaquenil be taken daily?

Depending on the indication, Plaquenil can be taken once or twice a day or once a week.

When Plaquenil Works

For Plaquenil to work, it must be stored in the body, which means that its effects may not be visible until several weeks after taking it, depending on the case.

How many days should I take Plaquenil?

The length of time Plaquenil should be taken depends on the diagnosis. In particular, long-term treatment of rheumatoid arthritis is indicated for up to 6 months or longer.

What Not to Eat When Taking Plaquenil

While taking Plaquenil, it is recommended that you follow a light diet to help your body work harder and fight the disease.

When to Take Plaquenil: Before or After Meals

It is preferable to take the medicine with a glass of milk, regardless of meals.

It is also possible to take Plaquenil with a meal and a little water.